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NMS-859
CAS No. 1449236-96-7
NMS-859( ZINC169324353 )
Catalog No. M26335 CAS No. 1449236-96-7
NMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 218 | In Stock |
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| 2MG | 129 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 283 | In Stock |
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| 25MG | 451 | In Stock |
|
| 50MG | 631 | In Stock |
|
| 100MG | 848 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 1655 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNMS-859
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NoteResearch use only, not for human use.
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Brief DescriptionNMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.
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DescriptionNMS-859 is an effective and covalent inhibitor of valosin-containing protein (VCP)/p97 with IC50s of 0.37 μM and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively.(In Vitro):NMS-859 suppresses the cell proliferation with IC50s of 3.0 μM and 3.5 μM in HeLa and HCT116 cell lines, respectively. NMS-859 shows weak inhibitory activity against VCPC522T.
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In VitroNMS-859 is a potent VCP inhibitor, with IC50s of 0.37 and 0.36 μM for wild-type VCP in the presence of 60 μM and 1 mM ATP in cells, respectively. NMS-859 shows very weak inhibitory activity against VCPC522T. NMS-859 also suppresses the proliferation of cells, with IC50s of 3.5 μM and 3.0 μM in HCT116 and HeLa cell lines, respectively.
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In Vivo——
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SynonymsZINC169324353
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PathwayOthers
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TargetOther Targets
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RecptorADC Cytotoxin| Microtubule/Tubulin
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Research Area——
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Indication——
Chemical Information
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CAS Number1449236-96-7
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Formula Weight349.79
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Molecular FormulaC15H12ClN3O3S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (142.94 mM)
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SMILESClCC(=O)Nc1cccc(NC2=NS(=O)(=O)c3ccccc23)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Francisco JA, et al. cAC10-vcMMAE, an anti-CD30-monomethyl auristatin E conjugate with potent and selective antitumor activity. Blood. 2003 Aug 15;102(4):1458-65.
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