MRZ 2-514( 8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one )

Catalog No. M26308 CAS No. 202808-11-5

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HNMR

HPLC

MSDS

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Product Name

MRZ 2-514
Note

Research use only, not for human use.
Brief Description

MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.
Description

MRZ 2-514 is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.(In Vitro):MRZ 2-514 is against peak AMPA-induced currents with IC50 of 72.7 μM.(In Vivo):In mice, MRZ 2-514 has anticonvulsive action in the MES model, and the effect is prolonged by probenecid.
In Vitro

MRZ 2-514 has IC50 values against peak AMPA-induced currents of 72.7 μM.
In Vivo

MRZ 2/514 has anticonvulsive action in the MES model in mice, and the effect is prolonged by probenecid.
Synonyms

8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one
Pathway

Membrane Transporter/Ion Channel
Target

NMDAR
Recptor

——
Research Area

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Indication

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1.Raymond KN, Dertz EA, Kim SS. Enterobactin: an archetype for microbial iron transport. Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3584-8.

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