Meclofenamic acid

Research use only, not for human use.

Meclofenamic acid is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.

Meclofenamic acid is a non-selective gap-junction blocker and a selective fat mass and obesity-associated (FTO) enzyme inhibitor. Meclofenamic acid has anti-inflammatory activities.

Meclofenamic acid (0-100 μM, 24 h) inhibits FTO demethylation in a dose-response manner.Meclofenamic acid inhibits enzyme cyclooxygenase, with an IC50 about 1 μM, thereby inhibiting the production of prostaglandins.Meclofenamic acid inhibits the release of 5-HETE and LTB4 from human neutrophils stimulated with calcium ionophore and antagonizes the response of tissues to certain prostaglandins. Western Blot Analysis Cell Line:HeLa cells Concentration:0, 12.5, 25, 50, 100 μM Incubation Time:24 h Result:Inhibited FTO demethylation in a dose-response manner, and elevates the levels of cellular m6A in mRNA by targeting FTO.

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Meclofenamate

Others

Other Targets

Major prion protein

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644-62-2

296.15

C14H11Cl2NO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (337.67 mM)

Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl

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(-20℃)

With Ice Pack

≥ 2 years