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LDC7559

CAS No. 2407782-01-6

LDC7559( —— )

Catalog No. M26276 CAS No. 2407782-01-6

LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 103 In Stock
5MG 132 In Stock
10MG 215 In Stock
25MG 432 In Stock
50MG 677 In Stock
100MG 995 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    LDC7559
  • Note
    Research use only, not for human use.
  • Brief Description
    LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.
  • Description
    LDC7559 inhibits gasdermin D (GSDMD) by blocking neutrophil extracellular trap (NET) at late stage.(In Vitro):LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    VHL
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2407782-01-6
  • Formula Weight
    349.38
  • Molecular Formula
    C20H19N3O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (286.22 mM)
  • SMILES
    O=C(NC1=CC=C2C(OCC3=CC(=NN3C2)C=4C=CC=CC4OC)=C1)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Farnaby W, et al. BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design. Nat Chem Biol. 2019 Jul;15(7):672-680.
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