JP1302 dihydrochloride

Research use only, not for human use.

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.

JP1302 dihydrochloride is a selective, high affinity antagonist of the alpha2C-adrenoceptor (α2C-adrenoceptor), with a Ki (binding affinity) value of 28 nM and a Kb value (antagonist activity) of 16 nM.

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Animal Model:Male Sprague Dawley rats (8 weeks old)Dosage:3 mg/kg Administration:IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion Result:Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression.

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Angiogenesis

Adrenergic Receptor

NF-κB

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1259314-65-2

441.4

C24H26Cl2N4

>98% (HPLC)

In Vitro:?H2O : 12.5 mg/mL (28.32 mM)

Cl.Cl.CN1CCN(CC1)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1

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(-20℃)

With Ice Pack

≥ 2 years