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Isoguvacine hydrochloride
CAS No. 68547-97-7
Isoguvacine hydrochloride( 1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride )
Catalog No. M26261 CAS No. 68547-97-7
Isoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 51 | In Stock |
|
| 50MG | 86 | In Stock |
|
| 100MG | 132 | In Stock |
|
| 500MG | 332 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIsoguvacine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionIsoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.
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DescriptionIsoguvacine hydrochloride is a GABA receptor agonist. Isoguvacine hydrochloride binds to rat synaptic cortical membranes and activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit GABAA receptors.(In Vitro):Treatment of 50 μM Isoguvacine to block epileptiform events in 2 of 6 organotypic hippocampal slice cultures, Isoguvacine dose-dependently inhibits hypomagnesium-induced epileptiform events. Isoguvacine binds to mouse forebrain synaptic membrane preparations and can specifically bind to GABA, muscimol and bicuculline, but not picrotoxin or diaminobutyric acid. The highest levels of binding are observed in the cerebellum, cortex and hippocampus.
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In VitroIsoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently.
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In Vivo——
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Synonyms1,2,3,6-tetrahydro-4-pyridinecarboxylic acid hydrochloride
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PathwayOthers
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TargetOther Targets
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RecptorNR2B-NMDA
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Research Area——
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Indication——
Chemical Information
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CAS Number68547-97-7
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Formula Weight163.6
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Molecular FormulaC6H10ClNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (611.25 mM)
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SMILESCl.OC(=O)C1=CCNCC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Ruslan I Stanika, et al. Coupling diverse routes of calcium entry to mitochondrial dysfunction and glutamate excitotoxicity. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9854-9.
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