Hydroxybupropion

Research use only, not for human use.

Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent.

Hydroxybupropion is the active metabolite of Bupropion metabolized by CYP2B6. Bupropion is an antidepressant and smoking-cessation agent. Hydroxybupropion inhibits norepinephrine uptake (IC50: 1.7 μM). Hydroxybupropion is also a nACh receptor antagonist more potent than Bupropion.(In Vitro):Hydroxybupropion shows stronger antitetrabenazine activity and has a lower LD50 value than the erythro- and threo- metabolites. Hydroxybupropion inhibits norepinephrine and dopamine uptake, antagonizes nicotine, and shows antidepressant effects in rodents.

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6-Hydroxybupropion | Hydroxybupropion, (+/-)- | Hydroxybupropione

Others

Other Targets

PEGs

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92264-81-8

255.74

C13H18ClNO2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (391.02 mM)

CC(NC(C)(C)CO)C(=O)c1cccc(Cl)c1

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(-20℃)

With Ice Pack

≥ 2 years