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H3B-120
CAS No. 2194903-42-7
H3B-120( —— )
Catalog No. M26243 CAS No. 2194903-42-7
H3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 81 | In Stock |
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| 2MG | 46 | In Stock |
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| 5MG | 73 | In Stock |
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| 10MG | 121 | In Stock |
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| 25MG | 264 | In Stock |
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| 50MG | 417 | In Stock |
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| 100MG | 668 | In Stock |
|
| 200MG | 923 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameH3B-120
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NoteResearch use only, not for human use.
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Brief DescriptionH3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.
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DescriptionH3B-120 is a highly selective, competitive, and allosteric carbamoyl phosphate synthetase 1 (CPS1) inhibitor (IC50: 1.5 μM; Ki: 1.4 μM) with anti-cancer activity.(In Vitro):H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min. H3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).
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In VitroH3B-120 has no inhibition of CPS2 activity of CAD (CPS2, aspartyl transcarbamylase, dihydroorotase).H3B-120 achieves inhibition by binding to an allosteric pocket situated between the integrating and ATP A domains. H3B-120 (25, 50, 75, 100 μM) inhibits urea production in a dose-dependent manner, although the cellular potency decreases significantly compared with enzymatic assays. The half-life of H3B-120 is only 40 min.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorAkt| p38 MAPK
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Research Area——
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Indication——
Chemical Information
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CAS Number2194903-42-7
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Formula Weight372.49
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Molecular FormulaC19H24N4O2S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (167.79 mM)
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SMILESCN(Cc1ccccc1)C(=O)N1CCC(CC1)C(=O)Nc1nc(C)cs1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.?Bai ZT,?et al. Inhibition of invasion by N-trans-feruloyloctopamine via AKT, p38MAPK and EMT related signals in hepatocellular carcinoma cells. Bioorg Med Chem Lett.?2017 Feb 15;27(4):989-993.
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