DOV-216,303 Free Base

CAS No. 66504-40-3

DOV-216,303 Free Base( DOV-216303 )

Catalog No. M26173 CAS No. 66504-40-3

DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 59 In Stock
2MG 36 In Stock
5MG 57 In Stock
10MG 93 In Stock
25MG 154 In Stock
50MG 221 In Stock
100MG 332 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    DOV-216,303 Free Base
  • Note
    Research use only, not for human use.
  • Brief Description
    DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM.
  • Description
    DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.(In Vivo):In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels.
  • In Vitro
    ——
  • In Vivo
    Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations. Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.Dosage:20 mg/kg.Administration:I.P. daily for 17 days.Result:Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.Dosage:20 mg/kg.Administration:I.P. once.Result:Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.
  • Synonyms
    DOV-216303
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    ——
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    66504-40-3
  • Formula Weight
    228.12
  • Molecular Formula
    C11H11Cl2N
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 125 mg/mL (547.96 mM)
  • SMILES
    Clc1ccc(cc1Cl)C12CC1CNC2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Julia López-Hernández, et al. Trans-Stilbenes in Commercial Grape Juices:Quantification Using HPLC Approaches. Int J Mol Sci. 2016 Oct 24;17(10):1769.
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