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Ca2+ channel agonist 1
CAS No. 1402821-24-2
Ca2+ channel agonist 1( —— )
Catalog No. M26083 CAS No. 1402821-24-2
Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 218 | In Stock |
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| 5MG | 188 | In Stock |
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| 10MG | 283 | In Stock |
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| 25MG | 452 | In Stock |
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| 50MG | 631 | In Stock |
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| 100MG | 848 | In Stock |
|
| 200MG | 1107 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameCa2+ channel agonist 1
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NoteResearch use only, not for human use.
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Brief DescriptionCa2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.
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DescriptionCa2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor nerve terminal dysfunction.(In Vitro):Ca2+ channel agonist 1 (Compound 13d) exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
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In VitroCa2+ channel agonist 1 (Compound 13d) is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2, with EC50s of 14.23 μM and 3.34 μM, respectively. Ca2+ channel agonist 1 exhibits a ca. 2-fold increased agonism and a 22-fold decreased cdk2 kinase activity versus the standard, (R)-roscovitine.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetCalcium Channel
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RecptorApoptosis| NF-κB
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Research Area——
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Indication——
Chemical Information
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CAS Number1402821-24-2
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Formula Weight354.458
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Molecular FormulaC19H26N6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 50 mg/mL (141.06 mM)
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SMILESCCCn1cnc2c(NCc3ccccc3)nc(N[C@H](CC)CO)nc12
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Cho K, et al. Inhibition of TNF-α-Mediated NF-κB Transcriptional Activity by Dammarane-Type Ginsenosidesfrom Steamed Flower Buds of Panax ginseng in HepG2 and SK-Hep1 Cells. Biomol Ther (Seoul). 2014 Jan;22(1):55-61.
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