COX-2-IN-1

Research use only, not for human use.

COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).

COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).(In Vitro):COX-2-IN-1(compound 5f) is an inhibitor of COX-1 and COX-2 with IC50s of >100 and 3.9 μM, respectively.

COX-2-IN-1(compound5f) is an inhibitor of COX-1 and COX-2 withIC50sof>100 and 3.9 μM, respctively. Comparison of 5b and COX-2-IN-1 shows that smaller halogen atom at 5th position on the indole ring enhances COX-2 enzyme inhibition activity, whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d, 5e and 5h) of the compound.

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Chromatin/Epigenetic

COX

Alkyl-Chain

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787623-48-7

442.84

C18H14ClF3N4O2S

>98% (HPLC)

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NS(=O)(=O)c1ccc(cc1)N1N=C(CC1c1c[nH]c2c(Cl)cccc12)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years