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Mefloquine
CAS No. 53230-10-7
Mefloquine( Lariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490 )
Catalog No. M26006 CAS No. 53230-10-7
Mefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 155 | In Stock |
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| 5MG | 148 | In Stock |
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| 10MG | 225 | In Stock |
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| 25MG | 376 | In Stock |
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| 50MG | 527 | In Stock |
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| 100MG | 739 | In Stock |
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| 200MG | 995 | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMefloquine
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NoteResearch use only, not for human use.
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Brief DescriptionMefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor.
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DescriptionMefloquine, a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research.
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In VitroMefloquine selectively inhibits prostate cancer (PCa) cell growth with an IC50 of ~10 μM. Mefloquine also induces hyperpolarization of the mitochondrial membrane potential (MMP), as well as ROS generation.Mefloquine (10 μM)-mediated ROS simultaneously downregulated Akt phosphorylation and activated ERK, JNK and AMPK signaling in PC3 cells.Mefloquine shows higher anti-SARS-CoV-2 activity than Hydroxychloroquine in VeroE6/TMPRSS2 and Calu-3 cells, with IC50 of 1.28 μM, IC90 of 2.31 μM, and IC99 of 4.39 μM in VeroE6/TMPRSS2 cells. Mefloquine inhibits viral entry after viral attachment to the target cell.
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In VivoMefloquine (5 mg/kg; i.p.; daily; 14 days) reverses the lower vertebral cancellous bone volume and bone formation; and has modest effects on cortical bone volume, thickness, and moment of inertia in old mice.
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SynonymsLariam | Ro 215998 | Ro-215998 | Ro215998 | WR 142490
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PathwayOthers
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TargetOther Targets
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RecptorBacterial
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Research Area——
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Indication——
Chemical Information
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CAS Number53230-10-7
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Formula Weight378.318
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Molecular FormulaC17H16F6N2O
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Purity>98% (HPLC)
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Solubility——
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SMILESO[C@H]([C@H]1CCCCN1)c1cc(nc2c(cccc12)C(F)(F)F)C(F)(F)F
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora.Ann Pharm Fr. 1997;55(6):262-8.
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