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ML251

CAS No. 1486482-16-9

ML251( ML251? )

Catalog No. M26000 CAS No. 1486482-16-9

ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 301 In Stock
5MG 275 In Stock
10MG 432 In Stock
25MG 715 In Stock
50MG 986 In Stock
100MG 1330 In Stock
200MG 1786 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    ML251
  • Note
    Research use only, not for human use.
  • Brief Description
    ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase.
  • Description
    ML251 is a potent novel nanomolar inhibitor of T. brucei and T. cruzi phosphofructokinase. ML251 inhibits T. brucei PFK (IC50=0.37 μM) and T. cruzi PFK (IC50=0.13 μM). ML251 can be used for the research of parasite.(In Vitro):ML251 produces modest dose-dependent toxicity.
  • In Vitro
    ML251 (T. brucei; 0~33.3 μg/mL) produces modest dose-dependent toxicity. Cell Cytotoxicity Assay Cell Line:T. brucei Concentration:0~33.3 μg/mL Incubation Time:Result:Dose-dependent reduction of cell viability.
  • In Vivo
    ——
  • Synonyms
    ML251?
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    Glucokinase
  • Recptor
    p53
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1486482-16-9
  • Formula Weight
    426.27
  • Molecular Formula
    C17H13Cl2N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 250 mg/mL (586.48 mM)
  • SMILES
    O=C(Cc(cc1)cc(Cl)c1Cl)Nc(cc1)ccc1S(Nc1nocc1)(=O)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pluquet O, et al. The cytoprotective aminothiol WR1065 activates p53 through a non-genotoxic signaling pathway involving c-Jun N-terminal kinase. J Biol Chem. 2003 Apr 4;278(14):11879-87.
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