DPA-714( —— )

Catalog No. M25016 CAS No. 958233-07-3

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	188	In Stock
5MG	180	In Stock
10MG	269	In Stock
25MG	499	In Stock
50MG	709	In Stock
100MG	1004	In Stock
200MG	1386	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

DPA-714
Note

Research use only, not for human use.
Brief Description

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM).
Description

DPA-714 is a high affinity translocator protein (TSPO) ligand (Ki=7 nM). It is designed with a fluorine atom in its structure, allowing labelling with fluorine -18 and in vivo imaging using positron emission tomography. [18F]DPA-714 successfully assesses for the specific imaging of inflammation in various models of neuroinflammation and in a brain tumor model.
In Vitro

——
In Vivo

[18F]DPA-714 binding significantly increases in vivo as a result of AD‐like pathology and age in APPswe×PS1Δe9 mice.
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

TSPO
Research Area

——
Indication

——

Chemical Information

CAS Number

958233-07-3
Formula Weight

398.47
Molecular Formula

C22H27FN4O2
Purity

>98% (HPLC)
Solubility

DMSO:41.67 mg/mL (104.57 mM; Need ultrasonic)
SMILES

CCN(CC)C(Cc1c2nc(C)cc(C)n2nc1-c(cc1)ccc1OCCF)=O
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.James ML, et al. DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization. J Nucl Med. 2008 May;49(5):814-22.

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