Cart
sales@molnova.com
TTA-A2
CAS No. 953778-63-7
TTA-A2( —— )
Catalog No. M25008 CAS No. 953778-63-7
TTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 280 | In Stock |
|
| 5MG | 255 | In Stock |
|
| 10MG | 407 | In Stock |
|
| 25MG | 746 | In Stock |
|
| 50MG | 1042 | In Stock |
|
| 100MG | 1376 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTTA-A2
-
NoteResearch use only, not for human use.
-
Brief DescriptionTTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating.
-
DescriptionTTA-A2 is a selective T-type calcium channel antagonist as a potent anticonvulsant that the Cav3.1 isoform plays a prominent role in mediating. TTA-A2 is equally potent against the Cav3.1 (a1G) and Cav3.2 (a1H) channels with IC50 values of 89 nM and 92 nM, respectively, at -80 and -100 mV holding potentials. TTA-A2 can be used for the research of a variety of human neurological diseases, including sleep disorders and epilepsy.
-
In Vitro——
-
In VivoAnimal Model:Wild-type and double Cav3.1/Cav3.3 knockout C57BL6/Sv129 background mices Dosage:10?mg/kg Administration:Oral gavage; 10?mg/kg; once daily; 5 days Result:Blocked active wake and promotes slow-wave sleep in wild-type mice but not mutant mice.
-
Synonyms——
-
PathwayGPCR/G Protein
-
TargetCalcium Channel
-
RecptorCav3.1 (a1G)|Cav3.2 (a1H)
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number953778-63-7
-
Formula Weight378.4
-
Molecular FormulaC20H21F3N2O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:10 mM
-
SMILESC[C@H](C1=NC=C(C=C1)OCC(F)(F)F)NC(=O)CC2=CC=C(C=C2)C3CC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Richard L Kraus, et al.In vitro characterization of T-type calcium channel antagonist TTA-A2 and in vivo effects on arousal in mice. J Pharmacol Exp Ther. 2010 Nov;335(2):409-17.
molnova catalog
related products
-
Etripamil
Etripamil displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells. Etripamil is an antagonist of short-acting L-type calcium-channel.
-
Cinacalcet metabolit...
Cinacalcet metabolite M4 is a metabolite of Cinacalcet. Cinacalcet is an allosteric agonist of Ca receptor.
-
Amlodipine Besylate
Amlodipine Besylate is a long-acting calcium channel blocker.
