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15-Lipoxygenase Inhibitor 1
CAS No. 928853-86-5
15-Lipoxygenase Inhibitor 1( 4-MMPB )
Catalog No. M24982 CAS No. 928853-86-5
15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 53 | In Stock |
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| 2MG | 29 | In Stock |
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| 5MG | 48 | In Stock |
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| 10MG | 79 | In Stock |
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| 25MG | 159 | In Stock |
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| 50MG | 254 | In Stock |
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| 100MG | 416 | In Stock |
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| 200MG | 588 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product Name15-Lipoxygenase Inhibitor 1
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NoteResearch use only, not for human use.
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Brief Description15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase.
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Description15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. 4-MMPB has IC50s of 19.5 μM and 19.1 μM for soybean 15-lipoxygenase (SLO) and human 15-lipoxygenase-1 (15-LOX-1), respectively. 4-MMPB has potential for the research of prostate cancer.(In Vitro):4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.
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In Vitro4-MMPB has an IC50 of 69.6 μM for DPPH bleaching.4-MMPB exhibits cytotoxic activity on human PC-3 and HFF3 cell lines.4-MMPB (41.48 μM; 72 hours) induces apoptosis and DNA damage in PC-3 Cells.Cell Viability Assay Cell Line:DU145 cells, PC-3 cells, HFF3 cells Concentration:9.57 μM, 19.94 μM, 39.88 μM, 79.77 μM,159.53 μM Incubation Time:24 hours, 48 hours, 72 hours Result:Inhibited cells viability (IC50=79.76 μM; 24 h, 51.05 μM; 48 h, 41.48 μM; 72 h for PC-3 cells, IC50=255.25 μM; 24 h, 130.81 μM; 48 h, 98.91 μM; 72 h for HFF3 cells).
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In Vivo——
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Synonyms4-MMPB
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PathwayOthers
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TargetOther Targets
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RecptorOthers
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Research Area——
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Indication——
Chemical Information
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CAS Number928853-86-5
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Formula Weight313.4
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Molecular FormulaC16H19N5S
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Purity>98% (HPLC)
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SolubilityDMSO:8mg/mL (25.52mM)
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SMILESCC1=C2C(=NC(=N1)N3CCN(CC3)C)SC4=CC=CC=C4N2
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nikpour M , Mousavian M , Mahdieh Davoodnejad…. Synthesis of new series of pyrimido[4,5- b ][1,4] benzothiazines as 15-lipoxygenase inhibitors and study of their inhibitory mechanism[J]. Medicinal Chemistry Research, 2013, 22(10):5036-5043.
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