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BT-13

CAS No. 924537-98-4

BT-13( —— )

Catalog No. M24974 CAS No. 924537-98-4

BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 93 In Stock
2MG 49 In Stock
5MG 84 In Stock
10MG 129 In Stock
25MG 220 In Stock
50MG 322 In Stock
100MG 460 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    BT-13
  • Note
    Research use only, not for human use.
  • Brief Description
    BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
  • Description
    BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Rats induced by ligation of left L5 and L6 spinal nerves.Dosage:5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.Administration:Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.Result:20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
  • Synonyms
    ——
  • Pathway
    Tyrosine Kinase
  • Target
    c-RET
  • Recptor
    RET
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    924537-98-4
  • Formula Weight
    517.54
  • Molecular Formula
    C23H27F4N3O4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 25 mg/mL (48.31 mM; Need ultrasonic)
  • SMILES
    O=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.
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