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BT-13
CAS No. 924537-98-4
BT-13( —— )
Catalog No. M24974 CAS No. 924537-98-4
BT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | In Stock |
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| 5MG | 132 | In Stock |
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| 10MG | 205 | In Stock |
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| 25MG | 349 | In Stock |
|
| 50MG | 519 | In Stock |
|
| 100MG | 743 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBT-13
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NoteResearch use only, not for human use.
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Brief DescriptionBT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
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DescriptionBT-13 is a selective agonist of glial cell line-derived neurotrophic factor (GDNF) receptor RET independently of GFLs. BT-13 promotes neurite growth from sensory neurons in vitro.
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In Vitro——
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In VivoAnimal Model:Rats induced by ligation of left L5 and L6 spinal nerves.Dosage:5-25 mg/kg, dissolved in sesame oil containing 5% DMSO.Administration:Subcutaneous injections on post-surgical day 1, 3, 5, 8, 10, and 12.Result:20 and 25mg/kg decreased mechanical hypersensitivity and normalized expression of sensory neuron markers in dorsal root ganglia.
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Synonyms——
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PathwayTyrosine Kinase
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Targetc-RET
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RecptorRET
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Research Area——
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Indication——
Chemical Information
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CAS Number924537-98-4
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Formula Weight517.54
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Molecular FormulaC23H27F4N3O4S
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Purity>98% (HPLC)
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SolubilityDMSO: 25 mg/mL (48.31 mM; Need ultrasonic)
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SMILESO=S(C1=CC=C(OC)C(N2CCN(C(C3=CC=C(F)C=C3C(F)(F)F)=O)CC2)=C1)(N(CC)CC)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Sidorova YA, et al. A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat. Front Pharmacol. 2017 Jun 21;8:365.
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