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SEC inhibitor KL-1

CAS No. 900308-84-1

SEC inhibitor KL-1( KL-1 )

Catalog No. M24926 CAS No. 900308-84-1

SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	87	In Stock
2MG	48	In Stock
5MG	79	In Stock
10MG	126	In Stock
25MG	216	In Stock
50MG	319	In Stock
100MG	454	In Stock
200MG	631	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

SEC inhibitor KL-1
Note

Research use only, not for human use.
Brief Description

SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).
Description

SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM). SEC inhibitor KL-1 is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4.
In Vitro

——
In Vivo

——
Synonyms

KL-1
Pathway

Others
Target

Other Targets
Recptor

SEC
Research Area

——
Indication

——

Chemical Information

CAS Number

900308-84-1
Formula Weight

345.78
Molecular Formula

C18H16ClNO4
Purity

>98% (HPLC)
Solubility

DMSO:41.67 mg/mL (120.51 mM; Need ultrasonic)
SMILES

CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)CC(=O)C2=CC(=CC=C2)OC
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.

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