SEN 12333( —— )

Catalog No. M24888 CAS No. 874450-44-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Get Quotation Bulk Inquiry Add to Cart

Product Name

SEN 12333
Note

Research use only, not for human use.
Brief Description

α7 nicotinic acetylcholine receptor (nAChR) agonist.
Description

α7 nicotinic acetylcholine receptor (nAChR) agonist.
In Vitro

In whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50= 12 μM). SEN12333 displays functional antagonism at histamine H3?receptors (IC50=103 nM) and weak agonist activity at human ganglionic?α3 nAChRs (IC50=8.5?μM).
In Vivo

SEN12333 (intraperitoneal?injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

AChR
Recptor

α7 nAChR
Research Area

——
Indication

——

Calculator

molnova catalog