Cart
sales@molnova.com
SEN 12333
CAS No. 874450-44-9
SEN 12333( —— )
Catalog No. M24888 CAS No. 874450-44-9
α7 nicotinic acetylcholine receptor (nAChR) agonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 54 | In Stock |
|
| 2MG | 31 | In Stock |
|
| 5MG | 49 | In Stock |
|
| 10MG | 83 | In Stock |
|
| 25MG | 167 | In Stock |
|
| 50MG | 263 | In Stock |
|
| 100MG | 423 | In Stock |
|
| 200MG | 609 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSEN 12333
-
NoteResearch use only, not for human use.
-
Brief Descriptionα7 nicotinic acetylcholine receptor (nAChR) agonist.
-
Descriptionα7 nicotinic acetylcholine receptor (nAChR) agonist.
-
In VitroIn whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50= 12 μM). SEN12333 displays functional antagonism at histamine H3?receptors (IC50=103 nM) and weak agonist activity at human ganglionic?α3 nAChRs (IC50=8.5?μM).
-
In VivoSEN12333 (intraperitoneal?injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetAChR
-
Recptorα7 nAChR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number874450-44-9
-
Formula Weight339.43
-
Molecular FormulaC20H25N3O2
-
Purity>98% (HPLC)
-
SolubilityDMSO:<33.94mg/ml
-
SMILESO=C(CCCCN1CCOCC1)Nc(cc1)ccc1-c1cnccc1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
molnova catalog
related products
-
Harmalol
Harmalol?is a bioactive?beta-carboline?and a member of the?harmala alkaloids
-
Solifenacin
Solifenacin (YM905 free base) is a novel muscarinic receptor antagonist, its pKis for M1, M2 and M3 receptors is of 7.6, 6.9 and 8.0, respectively.
-
Isopropamide Iodide
Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor antagonist which can be applied to the treatment of diseases affecting cognition including Alzheimer’s disease.
