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PAP-1

CAS No. 870653-45-5

PAP-1( 5-(4-Phenoxybutoxy)psoralen )

Catalog No. M24882 CAS No. 870653-45-5

PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 87 In Stock
2MG 54 In Stock
5MG 77 In Stock
10MG 131 In Stock
25MG 292 In Stock
50MG 509 In Stock
100MG 538 In Stock
200MG 769 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    PAP-1
  • Note
    Research use only, not for human use.
  • Brief Description
    PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
  • Description
    PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
  • In Vitro
    PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells with IC50 of 10 nM. Cell Proliferation Assay Cell Line:CCR7-TEM cells (anti-CD3 Ab stimulated)Concentration:2, 10, 25, 100 nM Incubation Time:30 minutes Result:Suppresses the Proliferation of CCR7-TEM cells with IC50 of 10 nM.
  • In Vivo
    PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats. Animal Model:9- to 11- week-old female Lewis rats Dosage:Intraperitoneal injection; three times daily for 48 hours Administration:0.3, 1, 3 mg/kg Result:Dose-dependently suppressed the DTH reaction.
  • Synonyms
    5-(4-Phenoxybutoxy)psoralen
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Potassium Channel
  • Recptor
    Kv1.3 channels
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    870653-45-5
  • Formula Weight
    350.36
  • Molecular Formula
    C21H18O5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:48 mg/mL (137 mM; Need ultrasonic);Water:Insoluble
  • SMILES
    O=C(C=C1)Oc2c1c(OCCCCOc1ccccc1)c(cco1)c1c2
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Schmitz A, et al. Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases. Mol Pharmacol. 2005 Nov;68(5):1254-70.
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