GW280264X( Carbamic acid )

Catalog No. M24871 CAS No. 866924-39-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

GW280264X
Note

Research use only, not for human use.
Brief Description

GW280264X is an inhibitor of ADAM17.
Description

GW280264X is an inhibitor of ADAM17 .
In Vitro

Cell Viability Assay Cell Line:Glioblastoma-initiating cells (GIC) GS-7 cells Concentration:0.1, 1, and 3 μM Incubation Time:48 hours Result:Proliferation of GIC is inhibited through inhibition of ADAM10 and ADAM17.
In Vivo

Animal Model:C57BL/6 miceDosage:100 ?μg/kg Administration:I.p. injected; every day for one week starting 4?h post-surgery Result:Showed significantly improved functional recovery compared to the control group.
Synonyms

Carbamic acid
Pathway

Others
Target

Other Targets
Recptor

ADAM17
Research Area

——
Indication

——

CAS Number

866924-39-2
Formula Weight

575.72
Molecular Formula

C28H41N5O6S
Purity

>98% (HPLC)
Solubility

DMSO:10 mM
SMILES

CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(=O)OCC1=CC=CC=C1)C(=O)NC2=NC=CS2)N(C=O)O
Chemical Name

——

1.Malemud C J . Inhibition of MMPs and ADAM/ADAMTS[J]. Biochemical Pharmacology, 2019.

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