Cart
sales@molnova.com
GW604714X?
CAS No. 853953-65-8
GW604714X?( 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- )
Catalog No. M24847 CAS No. 853953-65-8
GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 227 | In Stock |
|
| 10MG | 364 | In Stock |
|
| 25MG | 620 | In Stock |
|
| 50MG | 830 | In Stock |
|
| 100MG | 1144 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameGW604714X?
-
NoteResearch use only, not for human use.
-
Brief DescriptionGW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
-
DescriptionGW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
-
In VitroGW604714X inhibits the mitochondrial pyruvate carrier (MPC) with?Ki?value <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast?mitochondria.Inhibitor?titrations?of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their?Ki?(nM) of 56.0 nM and 0.057 nM for the GW604714X.GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values.
-
In Vivo——
-
Synonyms2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
-
PathwayOthers
-
TargetOther Targets
-
RecptorMitochondrial Metabolism
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number853953-65-8
-
Formula Weight471.46
-
Molecular FormulaC21H18FN5O5S
-
Purity>98% (HPLC)
-
SolubilityDMF:5mg/ml(10.61mM; need ultrasonic)
-
SMILESO=C(NC1=O)SC1=CC2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Hildyard J , Mml C , Dukes I D , et al. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier[J]. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005, 1707(2-3):221-230.
molnova catalog
related products
-
Azaleatin-3-rutinosi...
Azaleatin-3-rutinoside is a flavonol glycoside that can be isolated from Carya pecan.
-
Urocortin III, mouse...
Urocortin III, mouse TFA is a corticotropin-releasing factor (CRF)-related peptide. Urocortin III preferentially binds and activates CRF-R2. Urocortin III (Ucn3) is a known component of the behavioral stress response system. Urocortin III and CRF-R2 in the medial amygdala regulate complex social dynamics.
-
Bak BH3
This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.
