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GW604714X?

CAS No. 853953-65-8

GW604714X?( 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- )

Catalog No. M24847 CAS No. 853953-65-8

GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 364 In Stock
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Biological Information

  • Product Name
    GW604714X?
  • Note
    Research use only, not for human use.
  • Brief Description
    GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
  • Description
    GW604714X were found to be potent inhibitors of mitochondrial respiration supported by pyruvate.
  • In Vitro
    GW604714X inhibits the mitochondrial pyruvate carrier (MPC) with?Ki?value <0.1 μM in direct measurement of pyruvate transport into rat liver and yeast?mitochondria.Inhibitor?titrations?of pyruvate-dependent respiration by heart mitochondria gave values for the concentration of inhibitor binding sites and their?Ki?(nM) of 56.0 nM and 0.057 nM for the GW604714X.GW604714X inhibits the transport of 0.5 mM [14C]-l-lactate into rat red blood cells, mediated by the monocarboxylate transporter MCT1. GW604714X at 10 μM reduces the initial rate of uptake to 30% of control values.
  • In Vivo
    ——
  • Synonyms
    2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Mitochondrial Metabolism
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    853953-65-8
  • Formula Weight
    471.46
  • Molecular Formula
    C21H18FN5O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMF:5mg/ml(10.61mM; need ultrasonic)
  • SMILES
    O=C(NC1=O)SC1=CC2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hildyard J , Mml C , Dukes I D , et al. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier[J]. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2005, 1707(2-3):221-230.
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