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SHA 68
CAS No. 847553-89-3
SHA 68( —— )
Catalog No. M24842 CAS No. 847553-89-3
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
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| 5MG | 92 | In Stock |
|
| 10MG | 132 | In Stock |
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| 25MG | 302 | In Stock |
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| 50MG | 505 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSHA 68
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NoteResearch use only, not for human use.
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Brief DescriptionSHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
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DescriptionSHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
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In Vitro——
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In VivoAnimal Model:Male C57BL/6 mice age 8-12 weeksDosage:5 and 50 mg/kg Administration:i.p.Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.Animal Model:Male C57BL/6 mice age 8-12 weeks Dosage:1 mg/kg (Pharmacokinetic Analysis) Administration:i.p.Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorNPSR Asn107|NPSR Ile107
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Research Area——
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Indication——
Chemical Information
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CAS Number847553-89-3
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Formula Weight445.49
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Molecular FormulaC26H24FN3O3
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (561.18 mM; Need ultrasonic)
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SMILESO=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Neuropeptide FF
Endogenous antiopioid peptide and agonist at NPFF1 and NPFF2 receptors (Ki values are 2.82 and 0.21 nM respectively).
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M40
Potent, non-selective galanin receptor antagonist (Ki values are 1.82 and 5.1 nM at GAL1 and GAL2 respectively) that inhibits galanin (1-29) binding in rat brain in vitro (IC50 = 3 - 15 nM). Attenuates the antidepressant effects of fluoxetine and blocks galanin-induced food intake in vivo. Also exhibits weak partial agonist activity at peripheral GAL2 receptors at doses > 100 nM.
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Neuropeptide SF (mou...
Neuropeptide FF receptor agonist (Ki values are 48.4 and 12.1 nM for NPFF1 and NPFF2, respectively). Potentiates the antinociceptive action of morphine in vivo and reverses the loss of morphine potency in tolerant animals. Also increases the amplitude of the sustained current of heterologously expressed acid sensing ion channel 3 (ASIC3) (EC50 ~ 50 μM).
