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SHA 68
CAS No. 847553-89-3
SHA 68( —— )
Catalog No. M24842 CAS No. 847553-89-3
SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 65 | In Stock |
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| 5MG | 92 | In Stock |
|
| 10MG | 132 | In Stock |
|
| 25MG | 302 | In Stock |
|
| 50MG | 505 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameSHA 68
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NoteResearch use only, not for human use.
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Brief DescriptionSHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
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DescriptionSHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
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In Vitro——
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In VivoAnimal Model:Male C57BL/6 mice age 8-12 weeksDosage:5 and 50 mg/kg Administration:i.p.Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.Animal Model:Male C57BL/6 mice age 8-12 weeks Dosage:1 mg/kg (Pharmacokinetic Analysis) Administration:i.p.Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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RecptorNPSR Asn107|NPSR Ile107
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Research Area——
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Indication——
Chemical Information
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CAS Number847553-89-3
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Formula Weight445.49
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Molecular FormulaC26H24FN3O3
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Purity>98% (HPLC)
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SolubilityDMSO:250 mg/mL (561.18 mM; Need ultrasonic)
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SMILESO=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Galanin (1-29) (rat,...
Non-selective galanin receptor agonist (Ki values are 0.98, 1.48 and 1.47 nM for GAL1, GAL2 and GAL3 respectively). Anticonvulsant; prevents the occurrence of full kindled seizures in rats.
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Neuropeptide Y (22-3...
Neuropeptide Y (22-36), a 15 amino acid peptide, is a fragment of Neuropeptide Y.Neuropeptide Y (NPY) is a 36 amino-acid neuropeptide that is involved in various physiological and homeostatic processes in both the central and peripheral nervous systems. NPY has been identified as the most abundant peptide present in the mammalian central nervous system, which consists of the brain and spinal cord. It is secreted alongside other neurotransmitters such as GABA and glutamate.
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M617
Selective galanin GAL1 receptor agonist (Ki values are 0.23 and 5.71 nM for GAL1 and GAL2 receptors respectively). Enhances food consumption in rats following i.c.v. administration and reduces CAP-induced inflammatory pain.
