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Home - Products - GPCR/G Protein - Neuropeptide Y Receptor - SHA 68

SHA 68

CAS No. 847553-89-3

SHA 68( —— )

Catalog No. M24842 CAS No. 847553-89-3

SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    SHA 68
  • Note
    Research use only, not for human use.
  • Brief Description
    SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
  • Description
    SHA 68 is a potent and selective non-peptide antagonist of neuropeptide S receptor (NPSR)(NPSR Asn107 and NPSR Ile107 with IC50s of 22.0 and 23.8 nM, respectively).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male C57BL/6 mice age 8-12 weeksDosage:5 and 50 mg/kg Administration:i.p.Result:Reduced NPS-induced horizontal activity and vertical rearing and climbing.Animal Model:Male C57BL/6 mice age 8-12 weeks Dosage:1 mg/kg (Pharmacokinetic Analysis) Administration:i.p.Result:Had a T1/2 of 0.74 hours, a CL of 4.29 mL/min/kg, and a Vss of 2.53 L/kg.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Neuropeptide Y Receptor
  • Recptor
    NPSR Asn107|NPSR Ile107
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    847553-89-3
  • Formula Weight
    445.49
  • Molecular Formula
    C26H24FN3O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (561.18 mM; Need ultrasonic)
  • SMILES
    O=C(N1CC2N(C(OC2(C3=CC=CC=C3)C4=CC=CC=C4)=O)CC1)NCC5=CC=C(F)C=C5
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Okamura N, et al. Synthesis and pharmacological in vitro and in vivo profile of 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68), a selective antagonist of the neuropeptide S receptor.J Pharmacol Exp Ther. 2008 Jun;325(3):893-901.
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