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2-Iminobiotin hydrobromide

CAS No. 76985-52-9

2-Iminobiotin hydrobromide( Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE )

Catalog No. M24773 CAS No. 76985-52-9

2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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1 mL x 10 mM in DMSO 44 In Stock
25MG 28 In Stock
50MG 31 In Stock
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Biological Information

  • Product Name
    2-Iminobiotin hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
  • Description
    2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).(In Vitro):Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.
  • In Vitro
    Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.
  • In Vivo
    ——
  • Synonyms
    Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    iNOS|nNOS|NOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    76985-52-9
  • Formula Weight
    324.24
  • Molecular Formula
    C10H18BrN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL (51.37 mM)
  • SMILES
    [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zitta K , Peeters-Scholte C , Sommer L , et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology, 2018, 8:971.
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