2-Iminobiotin hydrobromide

CAS No. 76985-52-9

2-Iminobiotin hydrobromide( Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE )

Catalog No. M24773 CAS No. 76985-52-9

2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 44 In Stock
25MG 28 In Stock
50MG 31 In Stock
100MG Get Quote In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    2-Iminobiotin hydrobromide
  • Note
    Research use only, not for human use.
  • Brief Description
    2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).
  • Description
    2-Iminobiotin hydrobromide is a cyclic guanidino analog of biotin that acts as a reversible inhibitor of inducible nitric oxide synthase (iNOS) and neuronal NOS (nNOS; Ki of 21.8 and 37.5 μM for mouse iNOS and rat nNOS, respectively).(In Vitro):Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.
  • In Vitro
    Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.
  • In Vivo
    ——
  • Synonyms
    Guanidinobiotin | 2-IMINOBIOTIN HYDROBROMIDE
  • Pathway
    Immunology/Inflammation
  • Target
    NOS
  • Recptor
    iNOS|nNOS|NOS
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    76985-52-9
  • Formula Weight
    324.24
  • Molecular Formula
    C10H18BrN3O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL (51.37 mM)
  • SMILES
    [H][C@](CS[C@H]1CCCCC(O)=O)([C@]1([H])N2)NC2=N.Br
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zitta K , Peeters-Scholte C , Sommer L , et al. 2-Iminobiotin Superimposed on Hypothermia Protects Human Neuronal Cells from Hypoxia-Induced Cell Damage: An in Vitro Study[J]. Frontiers in Pharmacology, 2018, 8:971.
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