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Histrelin

CAS No. 76712-82-8

Histrelin( Supprelin LA )

Catalog No. M24769 CAS No. 76712-82-8

Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 99 In Stock
10MG 166 In Stock
25MG 305 In Stock
50MG 448 In Stock
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Biological Information

  • Product Name
    Histrelin
  • Note
    Research use only, not for human use.
  • Brief Description
    Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency.
  • Description
    Histrelin acetate is a nonapeptide analog of gonadotropin-releasing hormone (GnRH) with added potency. It is considered a GnRH agonist. Histrelin is used in the treatment of hormone-sensitive cancers of the prostate in men and uterine fibroids in women.
  • In Vitro
    Histrelin (10-100 nM) stimulates the release of vasopressin (VP) from from isolated rat hypothalamo-neurohypophysial explants.Histrelin (100 nM) stimulates oxytocin (OT) release from the rat hypothalamo-neurohypophysial system.
  • In Vivo
    Animal Model:Csfmop/Csfmop mice Dosage:0.001, 0.05, and 0.1 mg/kg Administration:Subcutaneous injection Result:Increased serum FSH concentrations by 4-fold.Animal Model:Rabbits Dosage:10, 30, or 100 μg /day Administration:Subcutaneous injection for 4 weeks Result:Caused a regression of the endometrial glands and a thinning of the stroma.
  • Synonyms
    Supprelin LA
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    76712-82-8
  • Formula Weight
    1323.5
  • Molecular Formula
    C66H86N18O12
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:Soluble; Water:Insoluble
  • SMILES
    CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Lewis KA, Goldyn AK, West KW, Eugster EA. A single histrelin implant is effective for 2 years for treatment of central precocious puberty. J Pediatr. 2013 Oct;163(4):1214-6. doi: 10.1016/j.jpeds.2013.05.033. Epub 2013 Jul 1. PubMed PMID: 23809043.
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