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GOT1 inhibitor-1

CAS No. 732973-87-4

GOT1 inhibitor-1( GOT1 inhibitor 2c )

Catalog No. M24741 CAS No. 732973-87-4

GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 215 In Stock
5MG 187 In Stock
10MG 312 In Stock
25MG 530 In Stock
50MG 733 In Stock
100MG 1042 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    GOT1 inhibitor-1
  • Note
    Research use only, not for human use.
  • Brief Description
    GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
  • Description
    GOT1 inhibitor-1 is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
  • In Vitro
    PDAC tumors are dependent upon a metabolic pathway involving aspartate aminotransferase 1 (glutamate-oxaloacetate transaminase 1 (GOT1)), for the maintenance of redox homeostasis and sustained proliferation. Small molecule inhibitors targeting this metabolic pathway may provide a novel way for cancer research.In the MDH coupled GOT1 enzymatic assay, GOT1 inhibitor-1 shows an inhibitory effect on GOT1 activity with an IC50 value of 8.2 uM.
  • In Vivo
    ——
  • Synonyms
    GOT1 inhibitor 2c
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    GOT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    732973-87-4
  • Formula Weight
    354.83
  • Molecular Formula
    C19H19ClN4O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:120mg/ml(338.19mM; need ultrasonic)
  • SMILES
    O=C(Nc(cc1)ccc1Cl)N(CC1)CCN1c1c(cc[nH]2)c2ccc1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Anglin J , Zavareh R B , Sander P N , et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma[J]. Bioorganic & Medicinal Chemistry Letters, 2018:S0960894X18303743.
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