Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).

QNZ (EVP4593) shows potent inhibitory activity toward both NF-κB activation and TNF-α production with IC50 of 11 nM and 7 nM, respectively.

B022 is a selective and potent NF-κB-induced kinase (NIK) inhibitor (Ki: 4.2 nM) and a chemical probe for treating liver inflammation and injury, protecting the liver from inflammation and injury caused by oxidative stress and toxins.