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Indirubin-3-monoxime
CAS No. 667463-82-3
Indirubin-3-monoxime( —— )
Catalog No. M24681 CAS No. 667463-82-3
Indirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 85 | In Stock |
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| 10MG | 123 | In Stock |
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| 25MG | 250 | In Stock |
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| 50MG | 368 | In Stock |
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| 100MG | 550 | In Stock |
|
| 200MG | 797 | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIndirubin-3-monoxime
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NoteResearch use only, not for human use.
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Brief DescriptionIndirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
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DescriptionIndirubin-3-monoxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
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In VitroIn cerebellar granule neurons (CGNs), Indirubin-3′-oxime blocks c-Jun phosphorylation induced by potassium withdrawal and prevented CGNs from apoptosis in a dose dependent manner. Indirubin-3′-oxime (IDR3O) (PC12 cells; 10 μM) significantly prevent 6OHDA-induced decrease of nuclear localized MEF2D expression.
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In VivoIndirubin-3′-oxime (0.05 or 0.5?mg/kg; i.p.; daily for 2 or 10 weeks) enhances tibial longitudinal growth in mice without adverse changes in bone thickness parameters. Animal Model:Three-week-old C57BL/6 mice Dosage:0.05 or 0.5?mg/kg Administration:I.p.; daily for 2 or 10 weeks Result:The tibial length of mice increased in a dose-dependent manner.
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Synonyms——
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PathwayAngiogenesis
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TargetCDK
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Recptorcdk
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Research Area——
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Indication——
Chemical Information
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CAS Number667463-82-3
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Formula Weight277.28
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Molecular FormulaC16H11N3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (360.65 mM)
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SMILESOc([nH]c1c2cccc1)c2-c([nH]c1c2cccc1)c2N=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dera A A , Rajagopalan P , Fayi M A , et al. Indirubin-3-monoxime and thymoquinone exhibit synergistic efficacy as therapeutic combination in in-vitro and in-vivo models of Lung cancer[J]. Archives of Pharmacal Research, 2020, 43(10).
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