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AH 7614

CAS No. 6326-06-3

AH 7614( —— )

Catalog No. M24637 CAS No. 6326-06-3

AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 55 In Stock
5MG 42 In Stock
10MG 75 In Stock
25MG 165 In Stock
50MG 295 In Stock
100MG 401 In Stock
200MG 522 In Stock
500MG 678 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    AH 7614
  • Note
    Research use only, not for human use.
  • Brief Description
    AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
  • Description
    AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
  • In Vitro
    AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.?AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70).AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
  • In Vivo
    AH7614 (50μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.AH7614 (50μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR120
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6326-06-3
  • Formula Weight
    351.42
  • Molecular Formula
    C20H17NO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35.1 mg/mL(100 mM);Ethanol:Insoluble;Water:Insoluble
  • SMILES
    O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014;24(14):3100-3.
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