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AH 7614

CAS No. 6326-06-3

AH 7614( —— )

Catalog No. M24637 CAS No. 6326-06-3

AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    AH 7614
  • Note
    Research use only, not for human use.
  • Brief Description
    AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
  • Description
    AH 7614 is a selective and potent free fatty acid receptor 4 (FFA4/GPR120) antagonist.
  • In Vitro
    AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca2+ response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.?AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC50=7.70).AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
  • In Vivo
    AH7614 (50μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.AH7614 (50μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    GPR120
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    6326-06-3
  • Formula Weight
    351.42
  • Molecular Formula
    C20H17NO3S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:35.1 mg/mL(100 mM);Ethanol:Insoluble;Water:Insoluble
  • SMILES
    O=S(C1=CC=C(C)C=C1)(NC2C3=C(OC4=C2C=CC=C4)C=CC=C3)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, et al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120). Bioorg Med Chem Lett. 2014;24(14):3100-3.
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