Vasicinone

Research use only, not for human use.

Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities.

Vasicinone may act as a hepatoprotective agent. (±)-Vasicinone has significant antitussive, expectorant, and bronchodilating activities, which can be used to treat respiratory disease.(S)-Vasicinone exhibits antiproliferative activity against human gastric cancer cells MCG-803.

Vasicinone (1~30 μM; 24 hours; SH-SY5Y cells) significantly reverses the paraquat-induced reduction in cell viability.Vasicinone (10 and 15 μM; 24 hours; SH-SY5Y cells) abates the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway, dose-dependently reduces the percentage of apoptotic cells and is capable of rescuing paraquat-induced apoptotic death.Vasicinone (10 and 15 μM; SH-SY5Y cells) attenuates the paraquat-induced accumulation of reactive oxygen species (ROS) and attenuates the paraquat-induced expression of apoptotic proteins.Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:1~30 μM Incubation Time:24 hours Result:Significantly reversed the paraquat-induced reduction in cell viability.Western Blot Analysis Cell Line:SH-SY5Y cells Concentration:10 and 15 μM Incubation Time:24 hours Result:Abated the paraquat-induced injury of SH-SY5Y cells by suppressing the MAPK signaling pathway.Apoptosis Analysis Cell Line:SH-SY5Y cells Concentration:10 and 15 μM Incubation Time:24 hours Result:Dose-dependently reduced the percentage of apoptotic cells.

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Others

Other Targets

Others

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486-64-6

202.21

C11H10N2O2

>98% (HPLC)

DMSO:10 mM

C1CN2C(=NC3=CC=CC=C3C2=O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years