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Home - Products - Cell Cycle/DNA Damage - Aurora Kinase - NU6140

NU6140

CAS No. 444723-13-1

NU6140( —— )

Catalog No. M24404 CAS No. 444723-13-1

NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 62 In Stock
2MG 33 In Stock
5MG 55 In Stock
10MG 93 In Stock
25MG 187 In Stock
50MG 295 In Stock
100MG 429 In Stock
200MG 600 In Stock
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Biological Information

  • Product Name
    NU6140
  • Note
    Research use only, not for human use.
  • Brief Description
    NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).
  • Description
    NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
  • In Vitro
    NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H, with IC50s of 6.6, 5.5, 15 and 3.9 μM, respectively.NU6140 increases catalytic activity of capase-9 and capase-3, causes increase in the sub-G1 apoptotic cell population.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    Aurora Kinase
  • Recptor
    Aurora A|Aurora B|CDK1/CyclinB|cdk2/cyclinA|CDK4/CyclinD|cdk5/p25|cdk7/cyclinH
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    444723-13-1
  • Formula Weight
    422.52
  • Molecular Formula
    C23H30N6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:250 mg/mL (591.69 mM; Need ultrasonic)
  • SMILES
    CCN(CC)C(C(C=C1)=CC=C1NC2=NC(OCC3CCCCC3)=C4C(N=CN4)=N2)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Pennati M, et al. Potentiation of apoptosis by the novel cyclin-dependent kinase inhibitor NU6140: a possible role for survivin down-regulation. Mol Cancer Ther. 2005 Sep;4(9):1328-37.
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