SBC-115337( —— )

Catalog No. M24388 CAS No. 423148-46-3

SBC-115337 is a PCSK9 inhibitor.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Biological Information

Product Name

SBC-115337
Note

Research use only, not for human use.
Brief Description

SBC-115337 is a PCSK9 inhibitor.
Description

SBC-115337 is a PCSK9 inhibitor.
In Vitro

The potent compound (SBC-115,337) shows an IC50 of 0.6 μM measured in an in vitro ELISA assay to monitor the effect of PCSK9 binding to the recombinant LDLR. SBC-115,337 at 1.2 μM induces more than tenfold upregulation of LDLR in HepG2 cells with respect to the control, increases uptake of fluorescently labeled DiI-LDL and loweres LDL-c levels in mice fed a high-fat diet.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

PSCK9
Research Area

——
Indication

——

Chemical Information

CAS Number

423148-46-3
Formula Weight

473.48
Molecular Formula

C29H19N3O4
Purity

>98% (HPLC)
Solubility

DMSO: 6mg/mL?(12.67mM;ultrasonic and warming and heat to 60℃)
SMILES

O=C(C1=CC2=CC=CC=C2O1)NC3=CC=C(C(NC4=CC=C(C5=NC6=CC=CC=C6O5)C=C4)=O)C=C3
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Lavecchia A , Cerchia C . Recent advances in developing PCSK9 inhibitors for lipid-lowering therapy[J]. Future medicinal chemistry, 2019, 11(5):423-441.

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