Cart
sales@molnova.com
PD146176
CAS No. 4079-26-9
PD146176( NSC168807 )
Catalog No. M24370 CAS No. 4079-26-9
PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 43 | In Stock |
|
| 5MG | 39 | In Stock |
|
| 10MG | 70 | In Stock |
|
| 25MG | 141 | In Stock |
|
| 50MG | 256 | In Stock |
|
| 100MG | 448 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NamePD146176
-
NoteResearch use only, not for human use.
-
Brief DescriptionPD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
-
DescriptionPD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki of 197 nM and IC50 of 0.54 μM. PD146176 reverses cognitive impairment, brain amyloidosis, and tau pathology by stimulating autophagy in aged triple transgenic mice.
-
In Vitro——
-
In VivoAnimal Model:Triple transgenic (3xTg) mice Dosage:80 mg/kg Administration:Chowing; 12 weeks Result:Significantly lower amyloid beta levels and deposition, less tau neuropathology, increased synaptic integrity, and autophagy activation.
-
SynonymsNSC168807
-
PathwayAutophagy
-
TargetAutophagy
-
Recptor15-LO|Autophagy
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number4079-26-9
-
Formula Weight237.32
-
Molecular FormulaC15H11NS
-
Purity>98% (HPLC)
-
SolubilityDMSO:25 mg/mL (105.34 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
-
SMILESC1C2=C(C3=CC=CC=C3S1)NC4=CC=CC=C24
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Bocan TM, et al. A specific 15-lipoxygenase inhibitor limits the progression and monocyte-macrophage enrichment of hypercholesterolemia-induced atherosclerosis in the rabbit [published correction appears in Atherosclerosis 1998 Jul;139(1):201]. Atherosclerosis. 1998;136(2):203-216.
molnova catalog
related products
-
Thymosin β4 acetate(...
Thymosin β4 (Tβ4) is a thymic hormone with multiple and different intracellular and extracellular activities affecting wound healing, inflammation, fibrosis and tissue regeneration.
-
STF-62247
STF-62247 is a small molecule Autophagy inducer that induces autophagy and selectively induces lethality in VHL-deficient RCC cells.
-
GC7 Sulfate
GC7 Sulfate is a potent inhibitor of deoxyhypusine synthase (DHS). Eukaryotic translation initiation factor 5A2 (eIF5A2) is the only known substrate for DHS, so GC7 inhibits the activation of eIF5A2 by inhibiting DHS activity.
