Cart
sales@molnova.com
Home - Products - Autophagy - Autophagy - MPP+ iodide

MPP+ iodide

CAS No. 36913-39-0

MPP+ iodide( —— )

Catalog No. M24329 CAS No. 36913-39-0

MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 30 In Stock
10MG 29 In Stock
25MG 60 In Stock
50MG 91 In Stock
100MG 152 In Stock
200MG Get Quote In Stock
500MG 369 In Stock
1G Get Quote In Stock
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    MPP+ iodide
  • Note
    Research use only, not for human use.
  • Brief Description
    MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra.
  • Description
    MPP+ iodide, the metabolite of a neurotoxin MPTP, causes symptom of Parkinson's disease (PD) in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ induces dopamine transporter (DAT) externalization in dopaminergic (DA) neurons, but internalization of serotonin transporter (SERT) in serotonergic (5-HT) neurons. MPP+ induces autophagic cell death in SH-SY5Y cells.
  • In Vitro
    Cell Viability Assay Cell Line:SH-SY5Y cells Concentration:1, 2, 3 mM Incubation Time:24 hours Result:SH-SY5Y cells were treated with MPP+, mimicking the progress of dopaminergic neurons loss in PD; Reduced cell viability in both dose-dependent (1, 2, 3 mM for 24 h) and time dependent (1 mM) manner.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    36913-39-0
  • Formula Weight
    297.13
  • Molecular Formula
    C12H12IN
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:62.5 mg/mL (210.34 mM; Need ultrasonic);Water:100 mg/mL (336.54 mM; Need ultrasonic)
  • SMILES
    C[n+](cc1)ccc1-c1ccccc1.[I-]
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • CUR5g

    CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.

  • Monochlorobimane

    Monochlorobimane (mBBr) is a fluorescent dye with a λex value of 380 nm and a λem value of 470 nm.Monochlorobimane can be used to measure glutathione (GSH) in cells.

  • Indole-3-Glyoxylyl C...

    It is an organic compunds with molecular fomula C10H6ClNO2.

Sign In Join Free