Garcinia lactone( (-)-Hydroxycitric acid lactone )

Catalog No. M24189 CAS No. 27750-13-6

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Garcinia lactone
Note

Research use only, not for human use.
Brief Description

Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.
Description

Garcinia lactone is an anti-obesity agent.Garcinia lactone was a potent inhibitor of ATP citrate lyase, which catalyzes the extramitochondrial cleavage of citrate to oxaloacetate and acetyl-CoA.
In Vitro

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In Vivo

(-)-Hydroxycitric acid lactone (1000-3000mg/kg; fed for a period of 4 weeks) significantly decreases body weight at 2000 and 3000 mg/kg in chicken. Animal Model:1-day-old male broiler chickens Dosage:1000, 2000, 3000 mg/kg Administration:Fed for a period of 4 weeksResult:Body weight and average daily gain (ADG) in the 2000 mg/kg and 3000 mg/kg were significantly lower.
Synonyms

(-)-Hydroxycitric acid lactone
Pathway

Endocrinology/Hormones
Target

ATPase
Recptor

ATP citrate lyase
Research Area

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Indication

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1.Jena BS, et al. Chemistry and biochemistry of (-)-hydroxycitric acid from Garcinia. J Agric Food Chem. 2002 Jan 2;50(1):10-22.

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