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Simufilam dihydrochloride
CAS No. 2480226-06-8
Simufilam dihydrochloride( PTI-125 dihydrochloride )
Catalog No. M24133 CAS No. 2480226-06-8
Simufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 98 | In Stock |
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| 5MG | 87 | In Stock |
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| 10MG | 139 | In Stock |
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| 25MG | 294 | In Stock |
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| 50MG | 373 | In Stock |
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| 100MG | 486 | In Stock |
|
| 200MG | 642 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSimufilam dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSimufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease.
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DescriptionSimufilam dihydrochloride is a low toxicity, orally active filamin A (FLNA) activator, which can be used for the research of Alzheimer's disease. Simufilam dihydrochloride preferentially binds altered FLNA and restores its native conformation, restoring receptor and synaptic activities and reducing its α7nAChR/TLR4 associations and downstream pathologies.
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In Vitro——
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In Vivo——
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SynonymsPTI-125 dihydrochloride
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PathwayOthers
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TargetOther Targets
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Recptorfilamin A (FLNA)
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Research Area——
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Indication——
Chemical Information
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CAS Number2480226-06-8
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Formula Weight332.3
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Molecular FormulaC15H23Cl2N3O
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Purity>98% (HPLC)
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Solubility——
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SMILES[H]Cl.O=C1N(CC2=CC=CC=C2)C3(CCN(C)CC3)NC1.[H]Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wang HY, et al. PTI-125 binds and reverses an altered conformation of filamin A to reduce Alzheimer's disease pathogenesis. Neurobiol Aging. 2017;55:99-114.
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