NRX-252262( —— )

Catalog No. M24123 CAS No. 2438637-61-5

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	330	In Stock
5MG	273	In Stock
10MG	432	In Stock
25MG	715	In Stock
50MG	986	In Stock
100MG	1330	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

Get Quotation Bulk Inquiry Add to Cart

Biological Information

Product Name

NRX-252262
Note

Research use only, not for human use.
Brief Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM)
Description

NRX-252262 is a potent enhancer of the interaction between β-Catenin, and its cognate E3 ligase, SCFβ-TrCP, induces mutant β-catenin degradation(EC50:3.8 nM).
In Vitro

NRX-252262 (35?μM) causes S33E/S37A mutant β-catenin degradation in cells.
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

SCF(β-TrCP)-E3 ligase
Research Area

——
Indication

——

Chemical Information

CAS Number

2438637-61-5
Formula Weight

545.36
Molecular Formula

C23H17Cl2F3N2O4S
Purity

>98% (HPLC)
Solubility

DMSO:8 mg/mL?(14.67 mM;?Need ultrasonic)
SMILES

O=C1C(C(N2CC3=C(C=C(OC)C(OC)=C3)C2)=O)=C(SC4=C(Cl)C=CC=C4Cl)C=C(C(F)(F)F)N1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Kyle R. Simonetta, et al. Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications. 2019 March.

Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog

Product			Quantity Required*
Name *			E-mail Address *
Organization *			Phone Number
Remarks