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Home - Products - Proteasome/Ubiquitin - NEDD8 - NAcM-OPT HCl(2089293-61-6 free base)

NAcM-OPT HCl(2089293-61-6 free base)

CAS No. 2416146-10-4

NAcM-OPT HCl(2089293-61-6 free base)( —— )

Catalog No. M24112 CAS No. 2416146-10-4

NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 85 In Stock
2MG 30 In Stock
5MG 45 In Stock
10MG 80 In Stock
25MG 143 In Stock
50MG 234 In Stock
100MG 383 In Stock
200MG Get Quote In Stock
500MG 909 In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    NAcM-OPT HCl(2089293-61-6 free base)
  • Note
    Research use only, not for human use.
  • Brief Description
    NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
  • Description
    NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    NEDD8
  • Recptor
    DCN1-UBE2M
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2416146-10-4
  • Formula Weight
    470.86
  • Molecular Formula
    C23H30Cl3N3O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=C(Cl)C(Cl)=C1)N(C2CCN(CCCC)CC2)CC3=CC=CC=C3.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.
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