Cart
sales@molnova.com
JHU 37160
CAS No. 2369979-68-8
JHU 37160( —— )
Catalog No. M24085 CAS No. 2369979-68-8
JHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 30 | In Stock |
|
| 10MG | 40 | In Stock |
|
| 25MG | 74 | In Stock |
|
| 50MG | 116 | In Stock |
|
| 100MG | 183 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameJHU 37160
-
NoteResearch use only, not for human use.
-
Brief DescriptionJHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
-
DescriptionJHU 37160 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
-
In VitroJHU37160 displays high DREADD affinity, with Kis of 1.9?nM and 3.6?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37160 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
-
In VivoJHU37160 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37160 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetAChR
-
RecptorM3 mAChR
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2369979-68-8
-
Formula Weight358.85
-
Molecular FormulaC19H20ClFN4
-
Purity>98% (HPLC)
-
SolubilityDMSO:72 mg/mL (200.65 mM);Ethanol:72 mg/mL (200.65 mM)
-
SMILESFC1=C2NC3=CC=C(Cl)C=C3N=C(N4CCN(CC)CC4)C2=CC=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
molnova catalog
related products
-
A 582941
A 582941 is a Selective agonist of α7 nAChR partialA-582941 was found to exhibit high-affinity binding and partial agonism at alpha7 nAChRs.?In vitro and in vivo studies indicated that A-582941 activates signaling pathways known to be involved in cognitive function such as ERK1/2 and CREB phosphorylation.?
-
1-Naphthyl acetate
1-Naphthyl acetate is usually used in a rapid staining method for identification of macrophages.?
-
Epiberberine (chlori...
Epiberberine chloride is an alkaloid isolated from Coptis chinensis acts as a potent AChE and BChE inhibitor and a non-competitive BACE1 inhibitor (IC50s: 1.07 6.03 and 8.55 μM).
