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JHU 37152
CAS No. 2369979-67-7
JHU 37152( —— )
Catalog No. M24084 CAS No. 2369979-67-7
JHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 72 | In Stock |
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| 10MG | 125 | In Stock |
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| 25MG | 259 | In Stock |
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| 50MG | 403 | In Stock |
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| 100MG | 592 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameJHU 37152
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NoteResearch use only, not for human use.
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Brief DescriptionJHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively.
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DescriptionJHU 37152 is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.8 nM and 8.7 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 5 nM and 0.5 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively.
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In VitroJHU37152 displays high DREADD affinity, with Kis of 1.8?nM and 8.7?nM for hM3Dq and hM4Di expressed in mouse brain sections.JHU37152 (1-1000 nM) selectively displaces [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.
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In VivoJHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.
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Synonyms——
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PathwayEndocrinology/Hormones
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TargetAChR
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RecptorM3 mAChR
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Research Area——
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Indication——
Chemical Information
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CAS Number2369979-67-7
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Formula Weight358.85
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Molecular FormulaC19H20ClFN4
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Purity>98% (HPLC)
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SolubilityDMSO:72 mg/mL (200.65 mM);Ethanol:24 mg/mL (66.88 mM)
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SMILESFC1=C2C(NC3=CC=C(Cl)C=C3N=C2N4CCN(CC)CC4)=CC=C1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Bonaventura J , Eldridge M , Hu F , et al. High-potency ligands for DREADD imaging and activation in rodents and monkeys[J]. Nature Communications, 2019, 10(1).
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