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Home - Products - Cell Cycle/DNA Damage - HDAC - JAK/HDAC-IN-1

JAK/HDAC-IN-1

CAS No. 2284621-75-4

JAK/HDAC-IN-1( —— )

Catalog No. M24039 CAS No. 2284621-75-4

JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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10MG 178 In Stock
25MG 340 In Stock
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Biological Information

  • Product Name
    JAK/HDAC-IN-1
  • Note
    Research use only, not for human use.
  • Brief Description
    JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.
  • Description
    JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in several hematological cell lines.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC|HDAC2|HDAC6|HDAC8|JAK1|JAK2|JAK3|Tyk2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2284621-75-4
  • Formula Weight
    450.32
  • Molecular Formula
    C19H21Cl2N7O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:20.83 mg/mL (46.26 mM; Need ultrasonic)
  • SMILES
    ONC(CCCCCn1ncc(Nc(nc2)nc(Nc(cc3)ccc3Cl)c2Cl)c1)=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.
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