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MEISi-2
CAS No. 2250156-71-7
MEISi-2( Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide )
Catalog No. M24027 CAS No. 2250156-71-7
MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameMEISi-2
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NoteResearch use only, not for human use.
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Brief DescriptionMEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.
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DescriptionMEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.
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In VitroMEISi-2 does not significantly inhibit the PBX-Luc-reporter.MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal.MEISi-2 down-regulates MEIS target gene expression.MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.
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In VivoMEISi-2 (10?μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content.MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF. Animal Model:4-6 week-old BALB/c mice Dosage:10?μM/100?μL Administration:Intraperitoneal injection, at day 1, day 4 and day 7 Result:Modulated HSC pool.
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SynonymsBenzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide
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PathwayOthers
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TargetOther Targets
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RecptorMEIS
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Research Area——
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Indication——
Chemical Information
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CAS Number2250156-71-7
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Formula Weight306.32
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Molecular FormulaC18H14N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : < 0.1 mg/mL (insoluble))
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SMILESO=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Turan R D , Albayrak E , Uslu M , et al. Development of Small Molecule MEIS Inhibitors that modulate HSC activity[J]. Scientific Reports.
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