MEISi-2

Research use only, not for human use.

MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.

MEISi-2 is a potent MEIS inhibitor (MEISi). MEISi-2 significantly inhibits MEIS-luciferase reporters in vitro.

MEISi-2 does not significantly inhibit the PBX-Luc-reporter.MEISi-2 induces MEIS dependent hematopoietic stem cell maintenance and self-renewal.MEISi-2 down-regulates MEIS target gene expression.MEISi-2 induces murine (LSKCD34low cells) and human (CD34+, CD133+, and ALDHhi cells) HSC self-renewal ex vivo.

MEISi-2 (10?μM; i.p.; at day 1, day 4 and day 7) functionally inhibits MEIS in vivo, thus they induces c-Kit+ cell, Sca1+ cell, CD150+ cell, LSK HSPCs, LSKCD34low HSC content and LSKCD150+CD48- HSC content.MEISi-2 down-regulates Meis1 expression, Hif-2α, and key CDKI gene expression including p16, p19, p19ARF. Animal Model:4-6 week-old BALB/c mice Dosage:10?μM/100?μL Administration:Intraperitoneal injection, at day 1, day 4 and day 7 Result:Modulated HSC pool.

Benzoic acid, 4-hydroxy-, 2-[(Z)-(2-oxo-1(2H)-naphthalenylidene)methyl]hydrazide

Others

Other Targets

MEIS

——

——

2250156-71-7

306.32

C18H14N2O3

>98% (HPLC)

In Vitro:?H2O : < 0.1 mg/mL (insoluble))

O=C(NN/C=C1C(C=CC2=C\1C=CC=C2)=O)C3=CC=C(O)C=C3

——

(-20℃)

With Ice Pack

≥ 2 years