GUN35901( [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]- )

Catalog No. M24026 CAS No. 2249435-90-1

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Product Name

GUN35901
Note

Research use only, not for human use.
Brief Description

GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
Description

GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
In Vitro

Western Blot Analysis Cell Line:Human foreskin fibroblasts Concentration:1 μM Incubation Time:Pretreated and then stimulated with 2′3′-cGAMP for 1 h Result:Suppressed 2′3′-cGAMP-induced STING oligomerization and phosphorylation.
In Vivo

Animal Model:4-wk-old Trex1?/? miceDosage:5 mg/kg Administration:I.p. 3 times weekly for a month Result:Improved survival of mice.Reduced severe multiorgan inflammation.Reduced serum antinuclear antibody.
Synonyms

[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-
Pathway

Immunology/Inflammation
Target

STING
Recptor

STING
Research Area

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Indication

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