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GUN35901
CAS No. 2249435-90-1
GUN35901( [1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]- )
Catalog No. M24026 CAS No. 2249435-90-1
GUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 63 | In Stock |
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| 5MG | 104 | In Stock |
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| 10MG | 160 | In Stock |
|
| 25MG | 267 | In Stock |
|
| 50MG | 408 | In Stock |
|
| 100MG | 600 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameGUN35901
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NoteResearch use only, not for human use.
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Brief DescriptionGUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
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DescriptionGUN35901 is a STING inhibitor, which inhibited the activation of the STING signal pathway and to prevent or treat a STING- mediated disease. It is a demethyl analogue of DUN99845.
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In VitroWestern Blot Analysis Cell Line:Human foreskin fibroblasts Concentration:1 μM Incubation Time:Pretreated and then stimulated with 2′3′-cGAMP for 1 h Result:Suppressed 2′3′-cGAMP-induced STING oligomerization and phosphorylation.
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In VivoAnimal Model:4-wk-old Trex1?/? miceDosage:5 mg/kg Administration:I.p. 3 times weekly for a month Result:Improved survival of mice.Reduced severe multiorgan inflammation.Reduced serum antinuclear antibody.
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Synonyms[1,1'-Biphenyl]-4-carboxamide, N-[3-[[(4-fluorophenyl)sulfonyl]amino]-4-hydroxyphenyl]-
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PathwayImmunology/Inflammation
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TargetSTING
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RecptorSTING
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Research Area——
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Indication——
Chemical Information
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CAS Number2249435-90-1
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Formula Weight——
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Molecular Formula——
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (216.22 mM)
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SMILESO=C(C1=CC=C(C2=CC=CC=C2)C=C1)NC3=CC=C(O)C(NS(=O)(C4=CC=C(F)C=C4)=O)=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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