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BC1618
CAS No. 2222094-18-8
BC1618( 2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]- )
Catalog No. M24005 CAS No. 2222094-18-8
BC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
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| 5MG | 72 | In Stock |
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| 10MG | 116 | In Stock |
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| 25MG | 235 | In Stock |
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| 50MG | 392 | In Stock |
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| 100MG | 584 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameBC1618
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NoteResearch use only, not for human use.
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Brief DescriptionBC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling.
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DescriptionBC1618 is an orally active Fbxo48 inhibitory compound, stimulates Ampk-dependent signaling. It promotes mitochondrial fission, facilitates autophagy and improves hepatic insulin sensitivity.
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In VitroWestern Blot Analysis Cell Line:BEAS-2B cells.Concentration:0-2 μM.Incubation Time:16 h.Result:Induced pAmpkα and pACC protein levels dose-dependently.
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In VivoAnimal Model:C57BL/6 mice.Dosage:2 or 10 mg/kg (challenged with LPS (3 mg/kg) for an additional 18 h).Administration:IP, once.Result:Reduced lung inflammation in endotoxin treated mice.Animal Model:C57BL/6 mice.Dosage:15 and 30 mg/kg/d.Administration:Drinking water for 3 months.Result:Exhibited no obvious toxicity.
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Synonyms2-Propanol, 1-[bis(phenylmethyl)amino]-3-[4-(trifluoromethyl)phenoxy]-
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PathwayMembrane Transporter/Ion Channel
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TargetAMPK
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RecptorAMPK|E1/E2/E3 Enzyme|Fbxo48|Mitophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number2222094-18-8
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Formula Weight415.45
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Molecular FormulaC24H24F3NO2
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Purity>98% (HPLC)
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SolubilityDMSO:100 mg/mL?(240.70 mM;?Need ultrasonic)
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SMILESOC(COC1=CC=C(C(F)(F)F)C=C1)CN(CC2=CC=CC=C2)CC3=CC=CC=C3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yuan Liu, et al. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306.
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