Ceftobiprole

Research use only, not for human use.

Ceftobiprole is a broad-spectrum cephalosporin with activity against Methicillin-resistant staphylococcus aureus.

Ceftobiprole is a broad-spectrum cephalosporin with activity against Methicillin-resistant staphylococcus aureus (MRSA; MIC90: 2 μg/mL).

Ceftobiprole (Ro 63-9141) has demonstrates activity against important gram-positive bacteria, including S. pneumonia (PRSP), Methicillin-resistant S. aureus (MRSA), and E. faecalis with MIC90 values of 0.25, 2, and 2 mcg/mL, respectively. Ceftobiprole has also demonstrated potent in vitro activity against several clinical isolates of community-associated Methicillin-resistant S. aureus (CA-MRSA), S. aureus (VISA), and S. aureus(VRSA), with a minimum inhibitory concentration (MIC) of 2 mcg/mL.Ceftobiprole is highly active against S. aureus, withMICs ranging from 0.12 to 4 mg/L (only one resistant strain,MIC of 4 mg/L). Furthermore, Ceftobiprole is twice more active on Methicillin-susceptible S. aureus (MSSA) strains with MIC50 and MIC90 of 0.5 mg/L than on MRSA strains with MIC50 and MIC90 of 1 mg/L. Moreover, Panton-Valentine leukocidin (PVL)+MRSA are slightly more susceptible to Ceftobiprole (MIC50 of 0.5 mg/L and MIC90 of 1 mg/L) than PVL-MRSA (MIC50 and MIC90 of 1 mg/L).

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Ro 63-9141 | BAL 9141

GPCR/G Protein

Antibacterial

Bacterial

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209467-52-7

534.57

C20H22N8O6S2

>98% (HPLC)

DMSO:5 mg/mL (9.35 mM; Need ultrasonic)

Nc1nc(/C(/C(N[C@H]([C@@H]2SCC(/C=C(\CCN3[C@@H]4CNCC4)/C3=O)=C(C(O)=O)N22)C2=O)=O)=N/O)ns1

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(-20℃)

With Ice Pack

≥ 2 years