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Vebicorvir

CAS No. 2090064-66-5

Vebicorvir( ABI-H0731 )

Catalog No. M23939 CAS No. 2090064-66-5

Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 126 In Stock
5MG 122 In Stock
10MG 202 In Stock
25MG 337 In Stock
50MG 461 In Stock
100MG 644 In Stock
200MG Get Quote In Stock
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Biological Information

  • Product Name
    Vebicorvir
  • Note
    Research use only, not for human use.
  • Brief Description
    Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
  • Description
    Vebicorvir is a first-generation hepatitis B virus (HBV) core protein inhibitor, has demonstrated effective antiviral activity.
  • In Vitro
    Vebicorvir (ABI-H0731) demonstrates inhibition of pgRNA, HBeAg, and HBsAg production, with EC50s of 2.68?μM, 4.95?μM, and 7.30?μM, respectively.Vebicorvir (ABI-H0731) is an inhibitor of pgRNA encapsidation and rcDNA synthesis.
  • In Vivo
    After i.v. administration, the drug rapidly distributes and decayes in a biphasic manner in all species tested. Plasma clearance values of ABI-H0731 were 8.05, 10.1, 14.7, and 4.86?ml/min/kg, representing 9, 16, 47, and 11% of liver blood flow, in mouse, rat, dog, and monkey, respectively.
  • Synonyms
    ABI-H0731
  • Pathway
    Microbiology/Virology
  • Target
    HBV
  • Recptor
    HBV DNA
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2090064-66-5
  • Formula Weight
    467.44
  • Molecular Formula
    C19H12F3N3O4S2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (213.93 mM)
  • SMILES
    O=C(c(cc1)cc(NC(c2c3cccc2)=O)c1S3(=O)=O)NCc1cnc(C(F)(F)F)s1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Huang Q, Cai D, Yan R, Li L, Zong Y, Guo L, Mercier A, Zhou Y, Tang A, Henne K, Colonno R. Preclinical Profile and Characterization of the Hepatitis B Virus Core Protein Inhibitor ABI-H0731. Antimicrob Agents Chemother. 2020 Oct 20;64(11):e01463-20.
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