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Home - Products - Chromatin/Epigenetic - Histone Demethylase - JNJ-64619178

JNJ-64619178

CAS No. 2086772-26-9

JNJ-64619178( —— )

Catalog No. M23934 CAS No. 2086772-26-9

JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 182 In Stock
5MG 170 In Stock
10MG 275 In Stock
25MG 567 In Stock
50MG 923 In Stock
100MG 1624 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    JNJ-64619178
  • Note
    Research use only, not for human use.
  • Brief Description
    JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM).
  • Description
    JNJ-64619178 is a selective, orally active, and pseudo-irreversible inhibitor of protein arginine methyltransferase 5 (IC50: 0.14 nM). It has effective activity In lung cancer.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Histone Demethylase
  • Recptor
    PRMT5
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2086772-26-9
  • Formula Weight
    483.36
  • Molecular Formula
    C22H23BrN6O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 120 mg/mL (248.26 mM; Need ultrasonic)
  • SMILES
    Nc1c(ccn2[C@H](C[C@H](CCc3ccc(cc(c(N)n4)Br)c4c3)[C@H]3O)[C@@H]3O)c2ncn1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Tongfei Wu, et al. Abstract 4859: JNJ-64619178, a selective and pseudo-irreversible PRMT5 inhibitor with potent in vitro and in vivo activity, demonstrated in several lung cancer models.
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