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SB 203186 hydrochloride
CAS No. 207572-69-8
SB 203186 hydrochloride( —— )
Catalog No. M23932 CAS No. 207572-69-8
SB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 25MG | 48 | In Stock |
|
| 50MG | 77 | In Stock |
|
| 100MG | 114 | In Stock |
|
| 200MG | 161 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSB 203186 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionSB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
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DescriptionSB 203186 hydrochloride is a potent 5-HT4 receptor antagonist.
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In VitroPretreatment with SB-203186 (10 μM) enhances the 5-HT-induced contractions of the antral strips.
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In VivoIntraduodenally administered SB-203186 (0.3-3 mg/kg) to new-born Camborough piglets produced blockade of 5-HT-evoked tachycardia which was maximal after 20 min and lasted for more than 3 h with 0.3 mg/kg.SB-203186 (0.1-3mg/kg, i.v.) surmountably antagonised 5-HT-evoked tachycardia in anaesthetized Yucatan minipigs or new-born Camborough piglets with similar potency.
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Synonyms——
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor5-HT4
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Research Area——
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Indication——
Chemical Information
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CAS Number207572-69-8
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Formula Weight308.81
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Molecular FormulaC16H20N2O2·HCl
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Purity>98% (HPLC)
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SolubilityH2O:100 mM
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SMILESO=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lofepramine
Lofepramine is a potent tricyclic antidepressant that is extensively metabolized to desipramine.
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PRX-07034
PRX-07034 is a selective antagonist of 5-HT6 receptor. It has cognition and memory-enhancing properties and potently decreases food intake and body weight in rodents.?PRX-07034 is both a potent (Ki = 4-8 nM) and highly selective 5-HT(6) receptor antagonist (≥100-fold selectivity for the 5-HT(6) receptor compared to 68 other GPCRs, ion channels, and transporters, except D(3) (Ki = 71 nM) and 5-HT(1B) (Ki = 260 nM) receptors.
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Cannabigerol
Cannabigerol is a high affinity α±2-adrenergic receptor agonist, moderate affinity 5-HT1A receptor antagonist, and low affinity CB1 receptor antagonist ; also binds to the CB2 receptor; it can relieve interocular pressure, which may be of benefit in the treatment of glaucoma.
