ERK-IN-3( ASN007 free base )

Catalog No. M23920 CAS No. 2055597-12-9

ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Size	Price / USD	Stock	Quantity
1 mL x 10 mM in DMSO	121	In Stock
5MG	120	In Stock
10MG	174	In Stock
25MG	282	In Stock
50MG	452	In Stock
100MG	Get Quote	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

ERK-IN-3
Note

Research use only, not for human use.
Brief Description

ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
Description

ERK-IN-3 is a potent and orally active inhibitor of ERK. It inhibits ERK1/2 with low single-digit nM IC50 values. It can be used for the research of cancers driven by RAS mutations.
In Vitro

——
In Vivo

——
Synonyms

ASN007 free base
Pathway

MAPK/ERK Signaling
Target

ERK
Recptor

ERK1|ERK2
Research Area

——
Indication

——

Chemical Information

CAS Number

2055597-12-9
Formula Weight

473.93
Molecular Formula

C22H25ClFN7O2
Purity

>98% (HPLC)
Solubility

DMSO:250 mg/mL (527.50 mM; Need ultrasonic)
SMILES

O=C(C1=CN(C2=NC(NC3CCOCC3)=NC=C2C)C=N1)N[C@@H](C4=CC(F)=CC(Cl)=C4)CN
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

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