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Emavusertib
CAS No. 1801344-14-8
Emavusertib( CA-4948 )
Catalog No. M23815 CAS No. 1801344-14-8
Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 72 | In Stock |
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| 2MG | 42 | In Stock |
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| 5MG | 67 | In Stock |
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| 10MG | 85 | In Stock |
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| 25MG | 169 | In Stock |
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| 50MG | 305 | In Stock |
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| 100MG | 524 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameEmavusertib
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NoteResearch use only, not for human use.
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Brief DescriptionEmavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
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DescriptionEmavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity.
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In Vitro——
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In VivoAnimal Model:Mice bearing OCI-LY10 tumorsDosage:25, 50, or 150 mg/kg (once daily), 12.5, 25, or 50 mg/kg (twice daily)Administration:Orally, once daily or twice daily, for 14 consecutive days Result:Induced tumor growth inhibition. Emavusertib administered as a twice-daily divided dose was equivalent to the corresponding once-daily dose with regards to antitumor activity, i.e., 12.5 mg/kg BID versus 25 mg/kg QD.
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SynonymsCA-4948
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PathwayAngiogenesis
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TargetFLT
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RecptorFLT3|IRAK4
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Research Area——
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Indication——
Chemical Information
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CAS Number1801344-14-8
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Formula Weight491.5
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Molecular FormulaC24H25N7O5
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Purity>98% (HPLC)
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SolubilityDMSO:27.78 mg/mL (56.52 mM; Need ultrasonic);H2O:< 0.1 mg/mL (insoluble)
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SMILESCC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=CC4=C(N=C3N5CC[C@H](C5)O)N=C(O4)N6CCOCC6
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Wiese MD, et al. Investigational IRAK-4 inhibitors for the treatment of rheumatoid arthritis. Expert Opin Investig Drugs. 2020 Apr 17:1-8.
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